4-Substituted prolines as organocatalysts for aldol reactions

被引：69

作者：

Bellis, E ^{[1
]}

Kokotos, G ^{[1
]}

机构：

[1] Univ Athens, Dept Chem, Organ Chem Lab, Athens 15771, Greece

来源：

TETRAHEDRON | 2005年 / 61卷 / 36期

关键词：

aldol reactions; amino acids; asymmetric catalysis; organocatalysts; 4-substituted proline;

D O I：

10.1016/j.tet.2005.06.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 4-substituted prolines were prepared and evaluated as organocatalysts for asymmetric aldol reactions. Using (2S,4R)4-camphorsulfonyloxy-proline, the aldol products were obtained in much higher enantiomeric excess in comparison to that observed using proline itself. In addition, the improved solubility of these new catalysts in organic solvents permits their use in lower sub-stoichiometric amounts compared to proline. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8669 / 8676

页数：8

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