Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders

被引：93

作者：

Manki, H

Kanba, S

Muramatsu, T

Higuchi, S

Suzuki, E

Matsushita, S

Ono, Y

Chiba, H

Shintani, F

Nakamura, M

Yagi, G

Asai, M

机构：

[1] KEIO UNIV, SCH MED, DEPT NEUROPSYCHIAT, SHINJUKU KU, TOKYO 160, JAPAN

[2] KURIHAMA NATL HOSP, NATL INST ALCOHOLISM, DEPT PSYCHIAT, KANAGAWA 239, JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1996年 / 40卷 / 1-2期

关键词：

dopamine receptor; dopamine transporter; polymorphism; mood disorder; bipolar disorder; major depression;

D O I：

10.1016/0165-0327(96)00035-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Disturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.

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页码：7 / 13

页数：7

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