Asymmetric membrane capsules for osmotic drug delivery - II. In vitro and in vivo drug release performance

被引：49

作者：

Thombre, AG ^{[1
]}

Cardinal, JR ^{[1
]}

DeNoto, AR ^{[1
]}

Gibbes, DC ^{[1
]}

机构：

[1] Pfizer Inc, Groton, CT 06340 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 1999年 / 57卷 / 01期

关键词：

asymmetric membrane capsule; in vitro and in vivo release; drug delivery mechanism; osmotic delivery;

D O I：

10.1016/S0168-3659(98)00101-1

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

In a previous paper, we described asymmetric membrane capsules and a phase inversion process for manufacturing them. In this paper, we describe the in vitro and in vivo drug release characteristics from these capsules. The capsule formulations were developed with model drugs to understand the variables that influenced drug release. Studies were also conducted to understand the drug release mechanism and it was shown that osmotic drug delivery was possible with asymmetric membrane capsules. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：65 / 73

页数：9

共 7 条

[1]

LIQUID-CHROMATOGRAPHIC ANALYSIS OF DOXAZOSIN IN HUMAN-SERUM WITH MANUAL AND ROBOTIC SAMPLE PREPARATION [J].