Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis

被引:3
作者
Holl-Wieden, A. [1 ]
Beer, M. [2 ]
Marx, A. [3 ]
Bonwg, R. [4 ]
Tappe, D. [5 ]
Girschick, H. J. [1 ]
机构
[1] Univ Wurzburg, Childrens Hosp, Sect Pediat Rheumatol Immunol & Infect Dis, D-97090 Wurzburg, Germany
[2] Univ Wurzburg, Dept Radiol, Sect Pediat Radiol, D-97090 Wurzburg, Germany
[3] Univ Wurzburg, Inst Pathol, D-97090 Wurzburg, Germany
[4] Univ Wurzburg, Dept Urol, D-97090 Wurzburg, Germany
[5] Univ Wurzburg, Inst Hyg & Microbiol, D-97090 Wurzburg, Germany
关键词
urachus; urachal infection; TNF alpha blockade; etanercept;
D O I
10.1007/s00296-008-0521-z
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Etanercept, a tumor necrosis factor (TNF) receptor alpha antagonist is licensed for the treatment in patients affected by polyarticular juvenile idiopathic arthritis, who do not tolerate or had an inadequate response to methotrexate. Infections related to immunosuppression by etanercept are of major concern. We report on a 17-year-old boy with enthesitis-related arthritis who developed a major infection of an urachal cyst 18 months after initiation of etanercept therapy, which required surgery. The urachus had not been symptomatic before.
引用
收藏
页码:819 / 822
页数:4
相关论文
共 10 条
[1]
Urachal anomalies: Defining the best diagnostic modality [J].
Cilento, BG ;
Bauer, SB ;
Retik, AB ;
Peters, CA ;
Atala, A .
UROLOGY, 1998, 52 (01) :120-122
[2]
Infectious complications of treatment with biologic agents [J].
Hamilton, CD .
CURRENT OPINION IN RHEUMATOLOGY, 2004, 16 (04) :393-398
[3]
The German etanercept registry for treatment of juvenile idiopathic arthritis [J].
Horneff, G ;
Schmeling, H ;
Biedermann, T ;
Foeldvari, I ;
Ganser, G ;
Girschick, HJ ;
Hospach, T ;
Huppertz, HI ;
Keitzer, R ;
Küster, RM ;
Michels, H ;
Moebius, D ;
Rogalski, B ;
Thon, A .
ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (12) :1638-1644
[4]
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial [J].
Klareskog, L ;
van der Heijde, D ;
de Jager, JP ;
Gough, A ;
Kalden, J ;
Malaise, M ;
Mola, EM ;
Pavelka, K ;
Sany, J ;
Settas, L ;
Wajdula, J ;
Pedersen, R ;
Fatenejad, S ;
Sanda, M .
LANCET, 2004, 363 (9410) :675-681
[5]
Cerebral demyelination in association with TNF-inhibition therapy in a 5-year-old girl with aseptic meningitis as the first symptom of Still's disease [J].
Kunzmann, S ;
Warmuth-Metz, M ;
Girschick, HJ .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2005, 34 (01) :76-78
[6]
Etanercept in children with polyarticular juvenile rheumatoid arthritis. [J].
Lovell, DJ ;
Giannini, EH ;
Reiff, A ;
Cawkwell, GD ;
Silverman, ED ;
Nocton, JJ ;
Stein, LD ;
Gedalia, A ;
Ilowite, NT ;
Wallace, CA ;
Whitmore, J ;
Finck, BK .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (11) :763-769
[7]
Long-term efficacy and safety of etanercept in children with polyarticular-course juvenile rheumatoid arthritis - Interim results from an ongoing multicenter, open-label, extended-treatment trial [J].
Lovell, DJ ;
Giannini, EH ;
Reiff, A ;
Jones, OY ;
Schneider, R ;
Olson, JC ;
Stein, LD ;
Gedalia, A ;
Ilowite, NT ;
Wallace, CA ;
Lange, M ;
Finck, BK ;
Burge, DJ .
ARTHRITIS AND RHEUMATISM, 2003, 48 (01) :218-226
[8]
An unusual presentation of an infected urachal cyst: case report and review of the literature [J].
Luo, CC ;
Huang, CS ;
Wu, WC ;
Chu, SM ;
Chao, HC .
EUROPEAN JOURNAL OF PEDIATRICS, 2004, 163 (4-5) :268-269
[9]
Etanercept therapy in rheumatoid arthritis - A randomized, controlled trial [J].
Moreland, LW ;
Schiff, MH ;
Baumgartner, SW ;
Tindall, EA ;
Fleischmann, RM ;
Bulpitt, KJ ;
Weaver, AL ;
Keystone, EC ;
Furst, DE ;
Mease, PJ ;
Ruderman, EM ;
Horwitz, DA ;
Arkfeld, DG ;
Garrison, L ;
Burge, DJ ;
Blosch, CM ;
Lange, MLM ;
McDonnell, ND ;
Weinblatt, ME .
ANNALS OF INTERNAL MEDICINE, 1999, 130 (06) :478-+
[10]
Experience with etanercept in an academic medical center: Are infection rates increased? [J].
Phillips, K ;
Husni, ME ;
Karlson, EW ;
Coblyn, JS .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2002, 47 (01) :17-21