Metabotropic glutamate 2/3 receptors as drug targets

被引：53

作者：

Marek, GJ ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 01期

关键词：

D O I：

10.1016/j.coph.2003.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Metabotropic glutamate receptors are a family of class III G-protein-coupled receptors comprising eight members (mGluR1-8), which are an attractive target in the central nervous system because of the widespread use of glutamate as the principal excitatory amino acid transmitter. The unique pharmacology of class III G-protein coupled receptors, their forebrain localization in key limbic-related cortical/thalamic/striatal/amygdaloid circuits, and the promise of subtle modulation of glutamatergic neurotransmission make these receptors intriguing targets for a wide variety of neuropsychiatric disorders.

引用

页码：18 / 22

页数：5

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