Serum protein binding of itraconazole and fluconazole in patients with diabetes mellitus

被引:26
作者
Arredondo, G [1 ]
Suárez, E [1 ]
Calvo, R [1 ]
Vazquez, JA [1 ]
García-Sanchez, J [1 ]
Martinez-Jordá, R [1 ]
机构
[1] Univ Basque Country, Sch Med, Dept Pharmacol, Vizcaya 48940, Spain
关键词
D O I
10.1093/jac/43.2.305
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The protein binding of itraconazole and fluconazole in the serum of patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus was investigated in vitro. The unbound percentage of itraconazole: in patients with IDDM and NIDDM was significantly higher than that in healthy volunteers. In contrast, there were no significant differences in fluconazole protein binding. A negative correlation was established between itraconazole protein binding and albumin concentration, and a positive correlation with free fatty acid concentration. The existence of a larger percentage of unbound itraconazole in diabetes patients could imply a change in drug disposition and an alteration in the effect of the drug. This should be taken into consideration in long duration treatment, especially in view of the non-linear kinetics of itraconazole.
引用
收藏
页码:305 / 307
页数:3
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