18F-FDG PET/CT in Lymphoma: Has Imaging-Directed Personalized Medicine Become a Reality?

被引：28

作者：

Barrington, Sally F. ^{[1
,2
]}

Johnson, Peter W. M. ^{[3
]}

机构：

[1] Kings Coll London, London SE1 7EH, England

[2] Kings Coll London, Guys & St Thomas PET Ctr, Div Imaging Sci & Biomed Engn, London, England

[3] Univ Southampton, Canc Res UK Ctr, Southampton, England

来源：

JOURNAL OF NUCLEAR MEDICINE | 2017年 / 58卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

positron emission tomography; lymphoma; precision medicine; POSITRON-EMISSION-TOMOGRAPHY; STAGE HODGKINS LYMPHOMA; RESPONSE-ADAPTED THERAPY; B-CELL LYMPHOMA; INTERIM PET; OPEN-LABEL; PHASE-II; TRIAL; CRITERIA; CT;

D O I：

10.2967/jnumed.116.181347

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

PET/CT using F-18-FDG is an essential part of the management of patients with lymphoma. Efforts to standardize PET acquisition and reporting, including the 5-point Deauville scale, have enabled PET to become a surrogate for treatment success or failure in common lymphoma subtypes. This review summarizes the key clinical-trial evidence that supports PET-directed personalized approaches in lymphoma. PET-guided therapy has improved outcomes in Hodgkin lymphoma, using less chemotherapy and more selective radiotherapy. Attempts to intensify chemotherapy in aggressive non-Hodgkin lymphomas have, however, proved ineffective in patients treated with rituximab and chemotherapy. Trials are under way to determine whether PET can obviate consolidation radiotherapy in patients with diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. More recently, PET has been reported to be a reliable predictor of outcome in follicular lymphoma requiring treatment, and prospective trials to test PET-guided therapy in this disease are anticipated.

引用

页码：1539 / 1544

页数：6

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