Therapeutic CD154 antibody for lupus: promise for the future?

被引：18

作者：

Kelsoe, G ^{[1
]}

机构：

[1] Duke Univ, Med Ctr 3010, Dept Immunol, Durham, NC 27710 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 10期

关键词：

D O I：

10.1172/JCI200320371

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease characterized by the production of pathogenic autoantibodies. A new study (see the related article beginning on page 1506) demonstrates that passive antibody specific for the TNF family member, CD 154, ameliorates disease by reducing levels of self-reactive antibody in the serum. This study demonstrates a substantial potential for anti-CD 154 antibody in the treatment of humoral autoimmunity.

引用

页码：1480 / 1482

页数：3

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