Intracellular signals and the cytoskeleton: The interactions of phosphoinositide kinases and small G proteins in adherence, ruffling and motility

被引：12

作者：

Carpenter, CL

机构：

[1] BETH ISRAEL HOSP, DEPT MED,DIV SIGNAL TRANSDUCT,HIM BLDG,ROOM 1026, 330 BROOKLINE AVE, BOSTON, MA 02215 USA

[2] BETH ISRAEL HOSP, DEPT MED, DIV HEMATOL ONCOL, BOSTON, MA 02215 USA

[3] HARVARD UNIV, SCH MED, BOSTON, MA 02215 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1996年 / 7卷 / 05期

关键词：

cytoskeleton; phosphoinositide kinases; small G proteins;

D O I：

10.1006/scdb.1996.0085

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many different cellular structures are formed by actin. Recent work has begun to identify signal transduction pathways that regulate actin. Small G proteins in the rho family mediate the formation of membrane ruffles, filopodia, stress fibers and focal adhesions. Phosphoinositide kinases interact with these small G proteins to activate them and transduce their signals. Protein kinases also transduce small G protein signals and regulate actin-based structures. In this review I will focus on the roles of small G proteins and phosphoinositide kinases in signaling pathways related to actin. (C) 1996 Academic Press Ltd

引用

页码：691 / 697

页数：7

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