Genomic organization of the ATM gene

被引：139

作者：

Uziel, T

Savitsky, K

Platzer, M

Ziv, Y

Helbitz, T

Nehls, M

Boehm, T

Rosenthal, A

Shiloh, Y

Rotman, G

机构：

[1] TEL AVIV UNIV, SACKLER SCH MED, DEPT HUMAN GENET, IL-69978 TEL AVIV, ISRAEL

[2] INST MOL BIOTECHNOL, DEPT GENOME ANAL, D-07745 JENA, GERMANY

[3] GERMAN CANC RES CTR, D-69120 HEIDELBERG, GERMANY

来源：

GENOMICS | 1996年 / 33卷 / 02期

关键词：

D O I：

10.1006/geno.1996.0201

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM. gene spans approximately 150 kb of genomic DNA and consists of 66 exons. The initiation codon falls within exon 4. The last exon is 3.8 kb and contains the stop codon and a 3'-untranslated region of about 3600 nucleotides. (C) 1996 Academic Press, Inc.

引用

页码：317 / 320

页数：4

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