Insulin and insulin-like growth factor I receptors: Similarities and differences in signal transduction

The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha -subunits and two transmembrane beta -subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution or subcellular localization, it can also be explained by structural differences in the beta -subunit, which may result in activation of specific substrates and signal pathways. Copyright (C) 2001 S. Karger AG, Basel.