Signal-induced repression: The exception or the rule in developmental signaling?

被引：29

作者：

Affolter, Markus ^{[1
]}

Pyrowolakis, George ^{[2
]}

Weiss, Alexander ^{[1
]}

Basler, Konrad ^{[3
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Univ Freiburg, Inst Biol 1, D-79104 Freiburg, Germany

[3] Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland

来源：

DEVELOPMENTAL CELL | 2008年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.devcel.2008.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways.

引用

页码：11 / 22

页数：12

共 88 条

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