Etiology of Chagas disease myocarditis:: autoimmunity, parasite persistence, or both?

被引：86

作者：

Gironès, N ^{[1
]}

Fresno, M ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol, Consejo Super Invest Cient, E-28049 Madrid, Spain

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 01期

关键词：

D O I：

10.1016/S1471-4922(02)00006-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In Chagas disease, caused by Trypanosoma cruzi, the scarcity of parasites in the chronic phase of the disease contrasts with the severe cardiac pathology observed in similar to30% of chronic patients, and suggests a role for autoimmunity as the origin of the pathology. Recent studies on parasite detection, however, suggest that parasite persistence is the main cause of Chagas disease. To date, there is no conclusive evidence for the pathogenic role of either autoimmunity or parasite-specific immunity. Here, the most recent evidence in favour of each hypothesis is discussed.

引用

页码：19 / 22

页数：4

共 37 条

[1]

Altclas J, 1999, Transpl Infect Dis, V1, P135, DOI 10.1034/j.1399-3062.1999.010207.x

[2] Myocardial parasite persistence in chronic Chagasic patients [J].

Añez, N ;

Carrasco, H ;

Parada, H ;

Crisante, G ;

Rojas, A ;

Fuenmayor, C ;

Gonzalez, N ;

Percoco, G ;

Borges, R ;

Guevara, P ;

Ramirez, JL .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (05) :726-732

[3]

Barbosa Jr A.d.A., 1984, REV SOC BRAS MED TRO, V17, P123, DOI DOI 10.1590/S0037-86821984000300003

[4] Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? [J].

Benoist, C ;

Mathis, D .

NATURE IMMUNOLOGY, 2001, 2 (09) :797-801

[5] Antibodies against the carboxyl-terminal end of the Trypanosoma cruzi ribosomal P proteins are pathogenic [J].

Bergami, PL ;

Scaglione, J ;

Levin, MJ .

FASEB JOURNAL, 2001, 15 (14) :2602-2612

[6]

BONFA E, 1993, J IMMUNOL, V150, P3917

[7]

CANÇADO J. Romeu, 2002, Rev. Inst. Med. trop. S. Paulo, V44, P29, DOI 10.1590/S0036-46652002000100006

[8] Autoimmunity in Chagas' disease - Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient [J].

CunhaNeto, E ;

Coelho, V ;

Guilherme, L ;

Fiorelli, A ;

Stolf, N ;

Kalil, J .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (08) :1709-1712

[9] MYOCARDITIS-INDUCING EPITOPE OF MYOSIN BINDS CONSTITUTIVELY AND STABLY TO I-A(K) ON ANTIGEN-PRESENTING CELLS IN THE HEART [J].

DONERMEYER, DL ;

BEISEL, KW ;

ALLEN, PM ;

SMITH, SC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) :1291-1300

[10] Prevalence of CD8+αβ T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62LLowLFA-1HighVLA-4High activation phenotype and expression of IFN-γ-inducible adhesion and chemoattractant molecules [J].

dos Santos, PVA ;

Roffê, E ;

Santiago, HC ;

Torres, RA ;

Marino, APMP ;

Paiva, CN ;

Silva, AA ;

Gazzinelli, RT ;

Lannes-Vieira, J .

MICROBES AND INFECTION, 2001, 3 (12) :971-984

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