Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry

被引：222

作者：

Moorhouse, Adam D.

Santos, Ana Mafalda

Gunaratnam, Mekala

Moore, Michael

Neidle, Stephen

Moses, John E.

机构：

[1] Univ London, Sch Pharm, CRUK Biomol Struct Grp, London WC1N 1AX, England

[2] Univ London, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 50期

关键词：

D O I：

10.1021/ja0661919

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration. Copyright © 2006 American Chemical Society.

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页码：15972 / 15973

页数：2

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