Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate in colon cancer cells

被引：107

作者：

Chintharlapalli, Sudhakar ^{[2
]}

Papineni, Sabitha ^{[1
]}

Abdelrahim, Maen ^{[3
]}

Abudayyeh, Ala ^{[4
]}

Jutooru, Indira ^{[1
]}

Chadalapaka, Gayathri ^{[1
]}

Wu, Fei ^{[5
]}

Mertens-Talcott, Susanne ^{[1
]}

Vanderlaag, Kathy ^{[1
]}

Cho, Sung Dae ^{[6
]}

Smith, Roger, III ^{[7
]}

Safe, Stephen ^{[1
,2
]}

机构：

[1] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA

[2] Texas A&M Univ Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX USA

[3] Orlando Reg Hlth Care, MD Anderson Canc Ctr, Orlando, FL USA

[4] Baylor Coll Med, Dept Gastroenterol, Houston, TX 77030 USA

[5] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[6] Chonbuk Natl Univ, Dept Oral Pathol, Sch Dent, Inst Oral Sci, Jeonju, South Korea

[7] Texas A&M Univ, Dept Vet Pathol, College Stn, TX 77843 USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CDODA-Me; anticarcinogenicity; miR-27a; colon cancer; cell cycle; GROWTH-FACTOR EXPRESSION; PROTEIN TRANSCRIPTION FACTORS; ACID-DERIVATIVES; DOWN-REGULATION; GASTRIC-CANCER; FACTOR FAMILY; UP-REGULATION; SP1; GENE; INHIBITION;

D O I：

10.1002/ijc.24530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic derivative of glycyrrhetinic acid, a triterpenoid phytochemical found in licorice extracts. CDODA-Me inhibited growth of RKO and SW480 colon cancer cells and this was accompanied by decreased expression of Sp1, Sp3 and Sp4 protein and mRNA and several Sp-dependent genes including survivin, vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1 or Flt-1). CDODA-Me also induced apoptosis, arrested RKO and SW480 cells at G(2)/M, and inhibited tumor growth in athymic nude mice bearing RKO cells as xenografts. CDODA-Me decreased expression of microRNA-27a (miR-27a), and this was accompanied by increased expression of 2 miR-27a-regulated mRNAs, namely ZBTB10 (an Sp repressor) and Myt-1 which catalyzes phosphorylation of cdc2 to inhibit progression of cells through G(2)/M. Both CDODA-Me and antisense miR-27a induced comparable responses in RKO and SW480 cells, suggesting that the potent anticarcinogenic activity of CDODA-Me is due to repression of oncogenic miR-27a. (C) 2009 UICC

引用

页码：1965 / 1974

页数：10

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