The use and limitations of current 'standard' toxicological data packages in the setting of acute reference doses

被引：1

作者：

Dewhurst, IC ^{[1
]}

机构：

[1] Pesticides Safety Directorate, York YO1 7PX, N Yorkshire, England

来源：

FOOD ADDITIVES AND CONTAMINANTS | 2000年 / 17卷 / 07期

关键词：

acute; pesticides; reference doses; risk-assessment; toxicology;

D O I：

10.1080/026520300412528

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To perform risk assessments for short term dietary intakes of pesticides it is necessary to determine an acceptable level of exposure from the available toxicity studies. This type of assessment is a relatively new development in regulatory toxicology and often the studies currently available are not optimal for such uses. The strengths and weaknesses of currently performed study types are presented. Consideration of the entire toxicity data base is essential.

引用

页码：611 / 615

页数：5