Decreased sTNF-RI in migraine patients?

被引：51

作者：

Empl, M

Sostak, P

Riedel, M

Schwarz, M

Müller, N

Förderreuther, S

Straube, A

机构：

[1] Univ Munich, Dept Neurol, D-8000 Munich, Germany

[2] Univ Munich, Dept Psychiat, D-8000 Munich, Germany

来源：

CEPHALALGIA | 2003年 / 23卷 / 01期

关键词：

migraine; sTNF-RI; pain generation;

D O I：

10.1046/j.1468-2982.2003.00453.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) have recently been found to have a pain-mediating function in addition to their immunological, proinflammatory function. According to the hypothesis of neurovascular inflammation in migraine, these two cytokines could contribute to migraine pain generation. We analysed IL-6 and its soluble receptors sIL-6R and sgp130 as well as TNF-alpha and its soluble receptor sTNF-RI in 27 migraine patients and eight headache-free controls. Migraine patients tended to have less sTNF-RI (794+/-158 pg/ml) than controls (945+/-137 pg/ml). No differences in cytokine concentrations were observed. If TNF-alpha plays a role in migraine physiopathology, migraine patients may lack sufficient antagonistic sTNF-RI to neutralize hyperalgesic TNF-alpha during a migraine attack.

引用

页码：55 / 58

页数：4

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