Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine

被引：63

作者：

Navarro, JT ^{[1
]}

Ribera, JM ^{[1
]}

Mate, JL ^{[1
]}

Granada, I ^{[1
]}

Juncà, J ^{[1
]}

Batlle, M ^{[1
]}

Millá, F ^{[1
]}

Feliu, E ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Haematol, Hosp Univ Germans Trias & Pujol, E-08193 Barcelona, Spain

来源：

LEUKEMIA & LYMPHOMA | 2003年 / 44卷 / 03期

关键词：

gammadelta T-cell lymphoma; hjepatosplenomegaly; Crohn's disease; azathioprine;

D O I：

10.1080/1042819021000035662

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatosplenic gammadelta T-cell lymphoma (HSgammadeltaTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSgammadeltaTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 55 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSgammadeltaTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.

引用

页码：531 / 533

页数：3

共 11 条

[1] Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic gamma delta T cell lymphoma [J].