CMV-specific T cell therapy

被引：56

作者：

Einsele, Hennann ^{[1
]}

Kapp, Markus ^{[1
]}

Grigoleit, Goetz Ulrich ^{[1
]}

机构：

[1] Univ Wurzburg, Med Klin & Poliklin 2, D-97080 Wurzburg, Germany

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2008年 / 40卷 / 01期

关键词：

D O I：

10.1016/j.bcmd.2007.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human cytomegalovirus (CMV) infection continues to be one of the most important and life threatening complications after allogencic stem cell transplantation (SCT). The reconstitution of CMV-specific T cell responses after SCT has been demonstrated to be protective against the development of CMV disease. To improve T cell immunity against CMV in bone marrow transplant patients, different strategies were explored. On one hand, CMV-specific T cells can be selected from the donor, and can be transferred to the patient without any further in vitro expansion. On the other hand, CMV-specific T cells can be activated and expanded in vitro by stimulation with antigen presenting cells (APCs) loaded with specific proteins or peptides. Here, we review the therapeutic application of CMV-specific T cells to fight CMV infection. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：71 / 75

页数：5

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