Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

被引：310

作者：

Mohty, M. ^{[1
,2
]}

Malard, F. ^{[1
,2
]}

Abecassis, M. ^{[3
]}

Aerts, E. ^{[4
]}

Alaskar, A. S. ^{[5
]}

Aljurf, M. ^{[6
]}

Arat, M. ^{[7
]}

Bader, P. ^{[8
]}

Baron, F. ^{[9
]}

Bazarbachi, A. ^{[10
]}

Blaise, D. ^{[11
]}

Ciceri, F. ^{[12
]}

Corbacioglu, S. ^{[13
]}

Dalle, J-H ^{[14
]}

Duarte, R. F. ^{[15
]}

Fukuda, T. ^{[16
]}

Huynh, A. ^{[17
]}

Masszi, T. ^{[18
]}

Michallet, M. ^{[19
]}

Nagler, A. ^{[20
]}

NiChonghaile, M. ^{[21
,22
]}

Pagluica, T. ^{[23
]}

Peters, C. ^{[24
]}

Petersen, F. B. ^{[25
]}

Richardson, P. G. ^{[26
]}

Ruutu, T. ^{[27
]}

Savani, B. N. ^{[28
,29
]}

Wallhult, E. ^{[30
]}

Yakoub-Agha, I. ^{[31
]}

Carreras, E. ^{[32
,33
,34
]}

机构：

[1] Hop St Antoine, Dept Hematol, F-75571 Paris 12, France

[2] Univ Paris 06, Paris, France

[3] Inst Portugues Oncol Francisco Gentil, Lisbon, Portugal

[4] Univ Zurich Hosp, Dept Haematol, CH-8091 Zurich, Switzerland

[5] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dept Oncol, King Abdulaziz Med City,Minist Natl Guard Hlth Af, Riyadh, Saudi Arabia

[6] King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia

[7] Sisli Florence Nightingale Hosp, HSCT Unit, Istanbul, Turkey

[8] Goethe Univ Frankfurt, Univ Hosp, Dept Children & Adolescents, Div Stem Cell Transplantat & Immunol, D-60054 Frankfurt, Germany

[9] Univ Liege, Dept Hematol, Liege, Belgium

[10] Amer Univ Beirut, Dept Internal Med, Beirut, Lebanon

[11] Inst J Paoli I Calmettes, Dept Hematol, Blood & Marrow Transplantat Program, F-13009 Marseille, France

[12] IRCCS, San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[13] Univ Regensburg, Dept Hematol Oncol & Stem Cell Transplant, D-93053 Regensburg, Germany

[14] Univ Paris 07, Hosp Robert Debre, Dept Hematol & Immunol, Paris, France

[15] Hosp Duran & Reynals, Inst Catala Oncol, Dept Haematol, Barcelona, Spain

[16] Natl Canc Ctr, HSCT Div, Tokyo, Japan

[17] Inst Univ Canc Toulouse Oncopole, Dept Hematol, Toulouse, France

[18] Semmelweis Univ, Dept Hematol & Stem Cell Transplantat, St Istvan & St Laszlo Hosp, Budapest Dept Internal Med 3, H-1085 Budapest, Hungary

[19] Univ Lyon 1, EST, Hosp Civils Lyon, Hematol Dept,Grp Hosp Sud, Pierre Benite, France

[20] Chaim Sheba Med Ctr, Hematol & Bone Marrow Transplantat, IL-52621 Tel Hashomer, Israel

[21] Univ Dublin Trinity Coll, Natl Stem Cell Transplant Unit Adults, Dept Haematol, St Jamess Hosp, Dublin 2, Ireland

[22] Univ Dublin Trinity Coll, Acad Dept Haematol, Dublin 2, Ireland

[23] Kings Coll Hosp London, Dept Haematol, London, England

[24] St Anna Childrens Hosp, Dept Pediat, Vienna, Austria

[25] LDS Hosp, Salt Lake City, UT USA

[26] Dana Farber Canc Inst, Dept Med Oncol, Div Hematol Malignancy, Boston, MA 02115 USA

[27] Univ Helsinki, Cent Hosp, Ctr Comprehens Canc, Helsinki, Finland

[28] Vanderbilt Univ, Dept Med, Hematol & Stem Cell Transplantat Sect, Div Hematol Oncol, Nashville, TN USA

[29] Vet Affairs Med Ctr, Nashville, TN 37212 USA

[30] Sahlgrens Univ Hosp, Dept Internal Med, Sect Haematol & Coagulat, Gothenburg, Sweden

[31] CHU Lille, Bone Marrow Transplantat Unit, F-59037 Lille, France

[32] Josep Carreras Leukaemia Res Inst, Barcelona, Spain

[33] Hosp Clin Barcelona, Dept Haematol, Barcelona, Spain

[34] Josep Carreras Fdn, Spanish Bone Marrow Donor Program, Barcelona, Spain

来源：

BONE MARROW TRANSPLANTATION | 2015年 / 50卷 / 06期

关键词：

HEPATIC VENOOCCLUSIVE-DISEASE; STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; URSODEOXYCHOLIC ACID; INTRAVENOUS BUSULFAN; CONDITIONING REGIMEN; ENDOTHELIAL ACTIVATION; SIGNIFICANT TOXICITY; PROSPECTIVE COHORT; RANDOMIZED-TRIAL;

D O I：

10.1038/bmt.2015.52

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/ VOD prevention and treatment in adults and children.

引用

页码：781 / 789

页数：9

共 69 条

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