Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

被引：13

作者：

Ye, Jia-Jun ^{[1
]}

Zhou, Tian-Biao ^{[2
]}

Zhang, Yun-Fang ^{[1
]}

Wang, Qi ^{[1
]}

Su, Yan-Yan ^{[1
]}

Tang, Jia-Min ^{[1
]}

Li, Hong-Yan ^{[1
]}

机构：

[1] Southern Med Univ, Huadu Dist Peoples Hosp, Dept Nephrol, Guangzhou 510800, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Nephrol, Guangzhou 510655, Guangdong, Peoples R China

来源：

AFRICAN HEALTH SCIENCES | 2016年 / 16卷 / 02期

关键词：

Vitamin D receptor (VDR); CYP24A1; end-stage renal disease (ESRD); GENE POLYMORPHISM; ASSOCIATION; SUSCEPTIBILITY; DIALYSIS; DENSITY;

D O I：

10.4314/ahs.v16i2.14

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls. Method: In this study, 24 ESRD patients and 24 healthy controls were included. Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20 +/- 0.32 vs 8.59 +/- 1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18 +/- 21 vs 7.78 +/- 1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P. 0.01). Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

引用

页码：462 / 467

页数：6

共 19 条

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