A comparison of 129S2/SvHsd and C57BL/6JO1aHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice

被引：137

作者：

Contet, C

Rawlins, JNP

Deacon, RMJ

机构：

[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England

[2] Ecole Normale Super, F-75005 Paris, France

来源：

BEHAVIOURAL BRAIN RESEARCH | 2001年 / 124卷 / 01期

基金：

英国惠康基金;

关键词：

mouse; test battery; strain comparison; cognition; anxiety; locomotion; genetic modification;

D O I：

10.1016/S0166-4328(01)00231-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mice from the 129S2/SvHsd (129) and C57BL/6JO1aHsd (C57) strains were assessed for performance on a test battery including sensorimotor, affective and cognitive measures, using established as well as modified paradigms. Marked strain differences were observed in measures of locomotion, motor coordination and anxiety the 129 mice were typically less active and more anxious. In contrast, the strains did not markedly differ in muscular strength, habituation to an open field or spatial working memory. The data provide baseline parameters of behaviour against which genetically modified lines derived from these particular parental strains can be assessed. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：33 / 46

页数：14

共 43 条

[1]

Anderson EE, 1938, PEDAGOG SEMIN J GEN, V53, P335

[2] IL-6 deficiency leads to increased emotionality in mice:: evidence in transgenic mice carrying a null mutation for IL-6 [J].