Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity

被引：210

作者：

Chakaroun, Rima ^{[1
]}

Raschpichler, Matthias ^{[1
]}

Kloeting, Nora ^{[2
]}

Oberbach, Andreas ^{[3
]}

Flehmig, Gesine ^{[1
]}

Kern, Matthias ^{[1
]}

Schoen, Michael R. ^{[4
]}

Shang, Edward ^{[5
]}

Lohmann, Tobias ^{[6
]}

Dressler, Miriam ^{[6
]}

Fasshauer, Mathias ^{[1
]}

Stumvoll, Michael ^{[1
]}

Bluether, Matthias ^{[1
]}

机构：

[1] Univ Leipzig, Dept Med, D-04103 Leipzig, Germany

[2] Univ Leipzig, IFB Obes Dis, Jr Res Grp Anim Models, D-04103 Leipzig, Germany

[3] Univ Leipzig, Dept Pediat Surg, D-04103 Leipzig, Germany

[4] Stadt Klinikum Karlsruhe, Clin Visceral Surg, D-76133 Karlsruhe, Germany

[5] Univ Leipzig, Dept Surg, D-04103 Leipzig, Germany

[6] Municipal Clin Dresden Neustadt, D-01129 Dresden, Germany

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2012年 / 61卷 / 05期

关键词：

TYPE-2; DIABETES-MELLITUS; METABOLIC SYNDROME; INSULIN-RESISTANCE; BARIATRIC SURGERY; INFLAMMATION; ATHEROSCLEROSIS; ADIPOKINE; MARKERS; FAT;

D O I：

10.1016/j.metabol.2011.10.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chemerin is a chemoattractant adipokine that regulates adipogenesis and may induce insulin resistance. Chemerin serum concentrations are elevated in obese, insulin-resistant, and inflammatory states in vivo. Here we investigate the role of omental (OM) and subcutaneous (SC) adipose tissue chemerin and CMKLR1 messenger RNA (mRNA) expression in human obesity. In addition, we test the hypothesis that changes in chemerin serum concentrations are primarily associated with reduced body fat mass in the context of 3 weight loss intervention studies. Chemerin serum concentration was measured in 740 individuals in a cross-sectional (n = 629) study including a subgroup (n = 161) for which OM and SC chemerin mRNA expression has been analyzed as well as in 3 interventions including 12 weeks of exercise (n = 60), 6 months of calorie-restricted diet (n = 19) studies, and 12 months after bariatric surgery (n = 32). Chemerin mRNA is significantly higher expressed in adipose tissue of patients with type 2 diabetes mellitus and correlates with circulating chemerin, body mass index (BMI), percentage body fat, C-reactive protein, homeostasis model assessment of insulin resistance, and glucose infusion rate in euglycemic-hyperinsulinemic clamps. CMKLR1 mRNA expression was not significantly different between the 2 fat depots. Obesity surgery-induced weight loss causes a significant reduction on both OM and SC chemerin expression. All interventions led to significantly reduced chemerin serum concentrations. Decreased chemerin serum concentrations significantly correlate with improved glucose infusion rate and reduced C-reactive protein levels independently of changes in BMI. Insulin resistance and inflammation are BMI-independent predictors of elevated chemerin serum concentrations. Reduced chemerin expression and serum concentration may contribute to improved insulin sensitivity and subclinical inflammation beyond significant weight loss. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：706 / 714

页数：9

共 26 条

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