Effects of Electroacupuncture Pretreatment on Inflammatory Response and Acute Kidney Injury in Endotoxaemic Rats

被引：42

作者：

Gu, G. ^{[1
]}

Zhang, Z. ^{[1
]}

Wang, G. ^{[1
]}

Han, F. ^{[1
]}

Han, L. ^{[2
]}

Wang, K. ^{[1
]}

Liu, J. ^{[3
]}

Li, W. ^{[3
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 3, Dept Anaesthesiol, Harbin 150081, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Pathol, Harbin 150081, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Dept Anaesthesiol, Harbin 150081, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 05期

关键词：

ACUTE KIDNEY INJURY; RATS; ELECTROACUPUNCTURE; LIPOPOLYSACCHARIDE; INFLAMMATORY RESPONSE; CYTOKINE; NITRITE; NUCLEAR FACTOR kappa B; ACUTE-RENAL-FAILURE; MESSENGER-RNA EXPRESSION; MULTIPLE ORGAN INJURY; ACUPUNCTURE STIMULATION; DOWN-REGULATION; ST-36; ZUSANLI; KAPPA-B; SEPSIS; ENDOTOXEMIA; ST36;

D O I：

10.1177/147323001103900521

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study investigated the effect of electroacupuncture pretreatment on the lipopolysaccharide (LPS)-induced inflammatory response and on acute kidney injury in adult male pathogen-free Wistar rats. Rats received electroacupuncture at the Zusanli (ST36) and Neiguan (PC6) acupoints, or electrical stimulation at sham points, for 30 min before stimulation with either 5 mg/kg LPS intravenously or normal saline. Plasma cytokines, plasma nitrite, renal inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-kappa B) activity were assessed 240 min after LPS or normal saline injection. Blood urea nitrogen (BUN), creatinine (Cr) and histopathological score for renal tubular damage were also measured. Electroacupuncture pretreatment significantly decreased LPS-induced plasma tumour necrosis factor-a and interleukin (IL)-1 beta, increased plasma IL-10, and decreased plasma nitrite, renal iNOS and NF-kappa B activity. It also significantly decreased LPS-induced BUN, Cr and the renal histopathological score. These findings suggest that electroacupuncture pretreatment at the ST36 and PC6 acupoints attenuated the LPS-induced inflammatory response and mitigated acute kidney injury.

引用

页码：1783 / 1797

页数：15

共 47 条

[1] Mediators of Inflammation in Acute Kidney Injury [J].

Akcay, Ali ;

Nguyen, Quocan ;

Edelstein, Charles L. .

MEDIATORS OF INFLAMMATION, 2009, 2009

[2]

[Anonymous], GUID CAR US LAB AN

[3] Sepsis and cytokines: Current status [J].

Blackwell, TS ;

Christman, JW .

BRITISH JOURNAL OF ANAESTHESIA, 1996, 77 (01) :110-117

[4] The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia [J].

Boost, K. A. ;

Flondor, M. ;

Hofstetter, C. ;

Platacis, I. ;

Stegewerth, K. ;

Hoegl, S. ;

Nguyen, T. ;

Muhl, H. ;

Zwissler, B. .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2007, 51 (07) :900-908

[5] Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].

Borovikova, LV ;

Ivanova, S ;

Zhang, MH ;

Yang, H ;

Botchkina, GI ;

Watkins, LR ;

Wang, HC ;

Abumrad, N ;

Eaton, JW ;

Tracey, KJ .

NATURE, 2000, 405 (6785) :458-462

[6] Protective effect of resin adsorption on septic plasma-induced tubular injury [J].

Cantaluppi, Vincenzo ;

Weber, Viktoria ;

Lauritano, Carola ;

Figliolini, Federico ;

Beltramo, Silvia ;

Biancone, Luigi ;

De Cal, Massimo ;

Cruz, Dinna ;

Ronco, Claudio ;

Segoloni, Giuseppe Paolo ;

Tetta, Ciro ;

Camussi, Giovanni .

CRITICAL CARE, 2010, 14 (01)

[7] N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia [J].

Chiao, CW ;

Lee, SS ;

Wu, CC ;

Su, MJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 535 (1-3) :291-300

[8] Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia [J].

Chiao, CW ;

Lee, SS ;

Wu, CC ;

Su, MJ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2005, 371 (01) :34-43

[9] Nuclear factor κB:: a pivotal role in the systemic inflammatory response syndrome and new target for therapy [J].

Christman, JW ;

Lancaster, LH ;

Blackwell, TS .

INTENSIVE CARE MEDICINE, 1998, 24 (11) :1131-1138

[10]

Chu Li-Chuan, 2005, Acta Anaesthesiol Taiwan, V43, P23

← 1 2 3 4 5 →