The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model

被引：14

作者：

Ishida, H ^{[1
]}

Murata, N ^{[1
]}

Yokoyama, M ^{[1
]}

Ishizuka, N ^{[1
]}

Takeuchi, I ^{[1
]}

Odaka, A ^{[1
]}

Shimomura, K ^{[1
]}

Fujioka, M ^{[1
]}

Idezuki, Y ^{[1
]}

机构：

[1] Saitama Med Sch, Saitama Med Ctr, Dept Surg, Kawagoe, Saitama 3058550, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2000年 / 14卷 / 06期

关键词：

colon; 26; colorectal cancer; laparoscopic surgery; pneumoperitoneum; pulmonary metastasis;

D O I：

10.1007/s004640000098

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model. Methods: BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pressures of 5, 10 or 15 mmHg; full laparotomy for 60 min; or anesthesia control. Cancer nodules on the lung surface 19 days postoperatively were compared between groups. Results: (a) As compared with the control group, pneumoperitoneum at 10 and 15 mmHg and laparotomy enhanced the growth of pulmonary metastases (p < 0.01). (b) The growth of metastases also was greater in laparotomy group mice than in mice undergoing pneumoperitoneum at 5 and 10 mmHg (p < 0.05). Conclusions: These results suggest that the effects of different insufflation pressures on the growth of pulmonary metastases are not identical, and that: pneumoperitoneum with high pressure may promote pulmonary metastases similar to those with laparotomy.

引用

页码：578 / 581

页数：4

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