Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

被引：608

作者：

Das, Mainak

Patil, Swanand

Bhargava, Neelima

Kang, Jung-Fong

Riedel, Lisa M.

Seal, Sudipta

Hickman, James J.

机构：

[1] Univ Cent Florida, NanoSci Technol Ctr, Orlando, FL 32826 USA

[2] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32826 USA

来源：

BIOMATERIALS | 2007年 / 28卷 / 10期

关键词：

adult spinal cord neurons; auto-catalytic; cerium oxide; nanoparticle; neuroprotection; nerve regeneration;

D O I：

10.1016/j.biomaterials.2006.11.036

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1918 / 1925

页数：8

共 34 条

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