Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis:: Relationship with inflammation, activity, and density of the bacterium

被引:49
作者
Di Mario, Francesco
Cavallaro, Lucas Giovanni
Moussa, Ali Mahamat
Caruana, Pietro
Merli, Roberta
Maini, Andrea
Bertolini, Simone
Dal Bo, Nadia
Rugge, Massimo
Cavestro, Giulia Martina
Aragona, Giovanni
Plebani, Mario
Franze, Angelo
Nervi, Giorgio
机构
[1] Univ Parma, Chair Gastroenterol, Dept Clin Sci, I-43100 Parma, Italy
[2] Univ Parma, Inst Pathol, I-43100 Parma, Italy
[3] Hosp Treviso, Gastroenterol Unit, Treviso, Italy
[4] Univ Hosp Padova, Dept Pathol, Padua, Italy
[5] Univ Hosp Padova, Dept Lab Med, Padua, Italy
[6] Hosp Parma, Gastroenterol Unit, Parma, Italy
关键词
activity; atrophy; chronic inflammation; Helicobacter pylori; density serum pepsinogens;
D O I
10.1007/s10620-006-9206-1
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = -0.33, P < .001) and intestinal metaplasia (r = -0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.
引用
收藏
页码:1791 / 1795
页数:5
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