The influence of obesity on short- and long-term graft and patient survival after renal transplantation

被引:87
作者
Aalten, Jeroen
Christiaans, Maarten H.
de Fijter, Hans
Hene, Ronald
van der Heijde, Jaap Homan
Roodnat, Joke
Surachno, Janto
Hoitsma, Andries
机构
[1] Univ Med Ctr St Radboud, Dept Nephrol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Hosp Maastricht, Dept Nephrol, Maastricht, Netherlands
[3] Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands
[4] Univ Med Ctr, Dept Nephrol, Utrecht, Netherlands
[5] Univ Groningen, Med Ctr, Dept Nephrol, Groningen, Netherlands
[6] Erasmus Univ, Med Ctr, Dept Nephrol, Rotterdam, Netherlands
[7] Acad Med Ctr, Dept Nephrol, Amsterdam, Netherlands
关键词
graft survival; obesity; patient survival; renal transplantation;
D O I
10.1111/j.1432-2277.2006.00367.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
To determine short- and long-term patient and graft survival in obese [body mass index (BMI) >= 30 kg/m(2)] and nonobese (BMI < 30 kg/m(2)) renal transplant patients we retrospectively analyzed our national-database. Patients 18 years or older receiving a primary transplant after 1993 were included. A total of 1871 patients were included in the nonobese group and 196 in the obese group. In the obese group there were significantly more females (52% vs. 38.6%, P < 0.01) and patients were significantly older [52 years (43-59) vs. 48 years (37-58); P < 0.05]. Patient survival and graft survival were significantly decreased in obese renal transplant recipients (1 and 5 year patient survival were respectively 94% vs. 97% and 81% vs. 89%, P < 0.01; 1 and 5 year graft survival were respectively 86% vs. 92% and 71% vs. 80%, P < 0.01). Initial BMI was an independent predictor for patient death and graft failure. This large retrospective study shows that both graft and patient survival are significantly lower in obese renal transplant recipients.
引用
收藏
页码:901 / 907
页数:7
相关论文
共 20 条
[1]   Morbid obesity does not preclude successful renal transplantation [J].
Bennett, WM ;
McEvoy, KM ;
Henell, KR ;
Valente, JF ;
Douzdjian, V .
CLINICAL TRANSPLANTATION, 2004, 18 (01) :89-93
[2]  
Drafts HH, 1997, CLIN TRANSPLANT, V11, P493
[3]   American Heart Association call to action: Obesity as a major risk factor for coronary heart disease [J].
Eckel, RH ;
Krauss, RM .
CIRCULATION, 1998, 97 (21) :2099-2100
[4]   Weight gain after renal transplantation is a risk factor for patient and graft outcome [J].
El-Agroudy, AE ;
Wafa, EW ;
Gheith, OE ;
El-Dein, ABS ;
Ghoneim, MA .
TRANSPLANTATION, 2004, 77 (09) :1381-1385
[5]   Demographics and trends in overweight and obesity in patients at time of kidney transplantation [J].
Friedman, AN ;
Miskulin, DC ;
Rosenberg, IH ;
Levey, AS .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 41 (02) :480-487
[6]  
GILL IS, 1993, TRANSPLANT P, V25, P1047
[7]   Impact of renal transplantation on survival in end-stage renal disease patients with elevated body mass index [J].
Glanton, CW ;
Kao, TC ;
Cruess, D ;
Agodoa, LYC ;
Abbott, KC .
KIDNEY INTERNATIONAL, 2003, 63 (02) :647-653
[8]  
Halme L, 1997, TRANSPLANT INT, V10, P284
[9]   Obesity does not portend a bad outcome for kidney transplant recipients [J].
Howard, RJ ;
Thai, VB ;
Patton, PR ;
Hemming, AW ;
Reed, AI ;
Van der Werf, WJ ;
Fujita, S ;
Karlix, JL ;
Scornik, JC .
TRANSPLANTATION, 2002, 73 (01) :53-55
[10]   The effect of obesity on renal transplant outcomes [J].
Johnson, DW ;
Isbel, NM ;
Brown, AA ;
Kay, TD ;
Franzen, K ;
Hawley, CM ;
Campbell, SB ;
Wall, D ;
Griffin, A ;
Nicol, DL .
TRANSPLANTATION, 2002, 74 (05) :675-681