Discovery and evaluation of potent, cysteine-based α4βl integrin antagonists

被引：4

作者：

Archibald, SC ^{[1
]}

Head, JC ^{[1
]}

Linsley, JM ^{[1
]}

Porter, JR ^{[1
]}

Robinson, MK ^{[1
]}

Shock, A ^{[1
]}

Warrellow, GJ ^{[1
]}

机构：

[1] Celltech Chirosci, Slough SL1 4EN, Berks, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00146-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acyclic, disulphide derivatives of cysteine have been identified as moderately potent antagonists of alpha 4 beta 1-mediated leukocyte cell adhesion to VCAM. This communication describes how they were discovered from a simple L-cystine derivative and using the structure-activity data of C*DThioPC* related cyclic peptides. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：993 / 995

页数：3

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