Vaccines: the Fourth Century

被引：170

作者：

Plotkin, Stanley A. ^{[1
]}

机构：

[1] Univ Penn, Doylestown, PA 18902 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 12期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; T-CELL RESPONSES; RANDOMIZED CONTROLLED-TRIAL; SEROGROUP-B MENINGOCOCCUS; SYNONYMOUS CODON USAGE; INFLUENZA VACCINE; JAPANESE ENCEPHALITIS; RHESUS MACAQUES; DNA VACCINE; CYTOMEGALOVIRUS INFECTIONS;

D O I：

10.1128/CVI.00290-09

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccine development, which began with Edward Jenner's observations in the late 18th century, has entered its 4th century. From its beginnings, with the use of whole organisms that had been weakened or inactivated, to the modern-day use of genetic engineering, it has taken advantage of the tools discovered in other branches of microbiology. Numerous successful vaccines are in use, but the list of diseases for which vaccines do not exist is long. However, the multiplicity of strategies now available, discussed in this article, portends even more successful development of vaccines.

引用

收藏

页码：1709 / 1719

页数：11

相关论文

共 125 条

[1]

Atkins Gregory J., 2008, Expert Reviews in Molecular Medicine, V10, P1, DOI 10.1017/S1462399408000859

[2] Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines [J].

Barnes, Dwight ;

Kunitomi, Mark ;

Vignuzzi, Marco ;

Saksela, Kalle ;

Andino, Raul .

CELL HOST & MICROBE, 2008, 4 (03) :239-248

[3] Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy [J].

Barry, Mazin ;

Cooper, Curtis .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2007, 7 (11) :1731-1737

[4] Meningococcal Factor H-Binding Protein Variants Expressed by Epidemic Capsular Group A, W-135, and X Strains from Africa [J].

Beernink, P. T. ;

Caugant, D. A. ;

Welsch, J. A. ;

Koeberling, O. ;

Granoff, D. M. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (09) :1360-1368

[5] Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults [J].

Belshe, Robert B. ;

Newman, Frances K. ;

Wilkins, Ken ;

Graham, Irene L. ;

Babusis, Elizabeth ;

Ewell, Marian ;

Frey, Sharon E. .

VACCINE, 2007, 25 (37-38) :6755-6763

[6] Live attenuated versus inactivated influenza vaccine in infants and young children [J].

Belshe, Robert B. ;

Edwards, Kathryn M. ;

Vesikari, Timo ;

Black, Steven V. ;

Walker, Robert E. ;

Hultquist, Micki ;

Kemble, George ;

Connor, Edward M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (07) :685-696

[7] Immunogenicity and safety of a novel IL-2-supplemented liposomal influenza vaccine (INFLUSOME-VAC) in nursing-home residents [J].

Ben-Yehuda, A ;

Joseph, A ;

Barenholz, Y ;

Zeira, E ;

Even-Chen, S ;

Louria-Hayon, I ;

Babai, I ;

Zakay-Rones, Z ;

Greenbaum, E ;

Galprin, I ;

Glück, R ;

Zurbriggen, R ;

Kedar, E .

VACCINE, 2003, 21 (23) :3169-3178

[8] A canarypox vector-expressing cytomegalovirus (CMV) phosphoprotein 65 induces long-lasting cytotoxic T cell responses in human CMV-seronegative subjects [J].

Berencsi, K ;

Gyulai, Z ;

Gönczöl, E ;

Pincus, S ;

Cox, WI ;

Michelson, S ;

Kari, L ;

Meric, C ;

Cadoz, M ;

Zahradnik, J ;

Starr, S ;

Plotkin, S .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (08) :1171-1179

[9] Synthetic Peptide Vaccines: The Quest to Develop Peptide Vaccines for Influenza, HIV and Alzheimer's Disease [J].

Bianchi, Elisabetta ;

Ingallinella, Paolo ;

Finotto, Marco ;

Joyce, Joseph ;

Liang, Xiaoping ;

Miller, Michael D. ;

Kinney, Gene G. ;

Ciliberto, Gennaro ;

Shiver, John W. ;

Pessi, Antonello .

PEPTIDES FOR YOUTH, 2009, 611 :121-123

[10] Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity [J].

Brockstedt, DG ;

Bahjat, KS ;

Giedlin, MA ;

Liu, W ;

Leong, M ;

Luckett, W ;

Gao, Y ;

Schnupf, P ;

Kapadia, D ;

Castro, G ;

Lim, JYH ;

Sampson-Johannes, A ;

Herskovits, AA ;

Stassinopoulos, A ;

Bouwer, HGA ;

Hearst, JE ;

Portnoy, DA ;

Cook, DN ;

Dubensky, TW .

NATURE MEDICINE, 2005, 11 (08) :853-860

← 1 2 3 4 5 6 7 8 9 10 →