Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines

被引:42
作者
Epelman, S
Bruno, TF
Neely, GG
Woods, DE
Mody, CH
机构
[1] Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Dept Med Sci, Calgary, AB T2N 4N1, Canada
[3] Univ Calgary, Dept Internal Med, Calgary, AB T2N 4N1, Canada
关键词
D O I
10.1128/IAI.68.8.4811-4814.2000
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pseudomonas aeruginosa infection of cystic fibrosis patients causes lung damage that is substantially orchestrated by cytokines. In this study, multi-gene probe analysis was used to characterize the ability of the P. aeruginosa mitogen, exoenzyme S, to induce proinflammatory and immunoregulatory cytokines and chemokines. Exoenzyme S strongly induced transcription of proinflammatory cytokines and chemokines (tumor necrosis factor alpha, interleukin-1 alpha [IL-1 alpha], IL-1 beta, IL-6, IL-8, MIP-1 alpha, MIP-1 beta, MCP-1, RANTES, and I-309), modest transcription of immunoregulatory cytokines (IL-10 and PL-12p40), and weak transcription of Th1 cytokines (IL-2 and gamma interferon). The response occurred early and subsided without evolving over time. These data suggest that cells responding to exoenzyme S would rapidly express proinflammatory cytokines and chemokines that may contribute to pulmonary inflammation in cystic fibrosis.
引用
收藏
页码:4811 / 4814
页数:4
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