Phosphatidylinositol 3,5-bisphosphate: metabolism and function

被引：18

作者：

Cooke, FT ^{[1
]}

机构：

[1] UCL, Dept Biochem & Mol Biol, London W1E 6BT, England

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2002年 / 407卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0003-9861(02)00487-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P-2) is the most recently discovered PtdInsP(2) isomer. It is likely that PtdIns(3,5)P-2 is ubiquitous to eukaryotes, and that it performs a number of important cellular functions, including vacuolar homeostasis, retrograde trafficking from the vacuole, and protein sorting at the multivesicular body. This review describes the metabolism of PtdIns(3,5)P-2 and discusses the potential functions for this lipid. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

收藏

页码：143 / 151

页数：9

相关论文

共 50 条

[1] PDGF-DEPENDENT TYROSINE PHOSPHORYLATION STIMULATES PRODUCTION OF NOVEL POLYPHOSPHOINOSITIDES IN INTACT-CELLS [J].

AUGER, KR ;

SERUNIAN, LA ;

SOLTOFF, SP ;

LIBBY, P ;

CANTLEY, LC .

CELL, 1989, 57 (01) :167-175

[2] Large-scale identification of genes important for apical growth in Saccharomyces cerevisiae by directed allele replacement technology (DART) screening [J].

Bidlingmaier S. ;

Snyder M. .

Functional & Integrative Genomics, 2002, 1 (6) :345-356

[3] GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro [J].

Blader, IJ ;

Cope, MJTV ;

Jackson, TR ;

Profit, AA ;

Greenwood, AF ;

Drubin, DG ;

Prestwich, GD ;

Theibert, AB .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (03) :581-596

[4] Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology [J].

Bonangelino, CJ ;

Catlett, NL ;

Weisman, LS .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :6847-6858

[5] Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p [J].

Bonangelino, CJ ;

Nau, JJ ;

Duex, JE ;

Brinkman, M ;

Wurmser, AE ;

Gary, JD ;

Emr, SD ;

Weisman, LS .

JOURNAL OF CELL BIOLOGY, 2002, 156 (06) :1015-1028

[6] Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment [J].

Bryant, NJ ;

Piper, RC ;

Weisman, LS ;

Stevens, TH .

JOURNAL OF CELL BIOLOGY, 1998, 142 (03) :651-663

[7] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains [J].

Burd, CG ;

Emr, SD .

MOLECULAR CELL, 1998, 2 (01) :157-162

[8] The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S-cerevisiae [J].

Cooke, FT ;

Dove, SK ;

McEwen, RK ;

Painter, G ;

Holmes, AB ;

Hall, MN ;

Michell, RH ;

Parker, PJ .

CURRENT BIOLOGY, 1998, 8 (22) :1219-1222

[9] MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae [J].

Desrivières, S ;

Cooke, FT ;

Parker, PJ ;

Hall, MN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (25) :15787-15793

[10] Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body [J].

Dove, SK ;

McEwen, RK ;

Mayes, A ;

Hughes, DC ;

Beggs, JD ;

Michell, RH .

CURRENT BIOLOGY, 2002, 12 (11) :885-893

← 1 2 3 4 5 →