The role of allergic rhinitis in nasal responses to sudden temperature changes

被引:134
作者
Graudenz, Gustavo Silveira
Landgraf, Richardt G.
Jancar, Sonia
Tribess, Arlindo
Fonseca, Simone G.
Fae, Kellen Cristhina
Kalil, Jorge
机构
[1] State Univ Sao Paulo, Div Immunol & Clin Allergy, Dept Internal Med, Sao Paulo, Brazil
[2] State Univ Sao Paulo, Dept Mech Engn, Polytech Inst, Sao Paulo, Brazil
[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, Sao Paulo, Brazil
[4] Millennium Inst, Inst Immunol Invest, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
indoor air quality; environmental illness; air conditioning; inflammatory mediators; SICK BUILDING SYNDROME; OFFICE BUILDINGS; RESPIRATORY SYMPTOMS; RISK-FACTORS; EOSINOPHIL; INVOLVEMENT; CHALLENGE; SYSTEMS; WORKERS;
D O I
10.1016/j.jaci.2006.07.005
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Air conditioning-induced rhinitis in allergic individuals is a common epidemiologic finding, but its physiopathology,is still controversial. The aim of this study was to describe and compare the effects of experimental air conditioning temperature changes on the nasal mucosa of individuals with persistent allergic rhinitis compared with a control group. Methods: A case-control challenge study was performed in a laboratory of thermal comfort with experimental twin challenge chambers set at a 12 C difference in temperature. A group of 32 patients with persistent allergic rhinitis and a group of 16 control subjects were exposed for 30 minutes, 3 times alternately in each chamber. Nasal symptom scores were recorded and nasal samples collected before, immediately after, and 24 and 48 hours after the challenge. Results: The rhinitis group showed a higher symptom score, epithelial shedding, percentage of eosinophils, total inflammatory cells, leukotriene C-4, eosinophil cationic protein, albumin, and tryptase levels compared with controls. There was also a significant increase in symptom score, total cells recovered, percentage of eosinophils, epithelial shedding, albumin, myeloperoxidase, and soluble intercellular adhesion molecule 1 in both groups compared with baseline levels. Conclusion: Sudden temperature changes led to a more pronounced inflammatory nasal response in the rhinitis group with the recruitment and activation of eosinophils. Clinical implications: Persistent allergic rhinitis is a risk factor for developing sudden temperature change-related rhinitis even in the absence of allergen exposure.
引用
收藏
页码:1126 / 1132
页数:7
相关论文
共 35 条
[1]  
American Society of Heating Refrigerating and Air-Conditioning Engineers, 2001, ASHRAE 64
[2]   Sick building syndrome - a wolf in sheep's clothing [J].
Bardana, EJ .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1997, 79 (04) :283-293
[3]   The heterogeneity of allergic phenotypes: genetic and environmental interactions [J].
Bonini, S ;
Rasi, G ;
Torre, A ;
D'Amato, M ;
Matricardi, PM .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2001, 87 (06) :48-51
[4]   Allergic rhinitis and its impact on asthma [J].
Bousquet, J ;
van Cauwenberge, P ;
Khaltaev, N ;
Ait-Khaled, N ;
Annesi-Maesano, I ;
Bachert, C ;
Baena-Cagnani, C ;
Bateman, E ;
Bonini, S ;
Canonica, GW ;
Carlsen, KH ;
Demoly, P ;
Durham, SR ;
Enarson, D ;
Fokkens, WJ ;
van Wijk, RG ;
Howarth, P ;
Ivanova, NA ;
Kemp, JP ;
Klossek, JM ;
Lockey, RF ;
Lund, V ;
Mackay, I ;
Malling, HJ ;
Meltzer, EO ;
Mygind, N ;
Okunda, M ;
Pawankar, R ;
Price, D ;
Scadding, GK ;
Simons, FER ;
Szczeklik, A ;
Valovirta, E ;
Vignola, AM ;
Wang, DY ;
Warner, JO ;
Weiss, KB .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :S147-S334
[5]   HOST SUSCEPTIBILITY TO INDOOR AIR-POLLUTION [J].
BROOKS, SM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (02) :344-351
[6]  
CHURCH MK, 2003, MIDDLETONS ALLERGY P, P190
[7]  
Galvão Clóvis Eduardo Santos, 2004, Sao Paulo Med. J., V122, P204, DOI 10.1590/S1516-31802004000500005
[8]   Elevations of local leukotriene C4 levels during viral upper respiratory tract infections [J].
Gentile, DA ;
Fireman, P ;
Skoner, DP .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2003, 91 (03) :270-274
[9]  
Giembycz MA, 1999, PHARMACOL REV, V51, P213
[10]  
Gilain L, 2000, Ann Otolaryngol Chir Cervicofac, V117, P91