Comprehensive kinetic screening of palladium catalysts for Heck reactions

被引：18

作者：

Blackmond, Donna G. ^{[1
]}

Schultz, Thomas

Mathew, Jinu S.

Loew, Caroline

Rosner, Thorsten

Pfaltz, Andreas

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn & Chem Technol, London SW7 2AZ, England

[3] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

[4] Merck Res Labs, Dept Proc Res, Catalysis Grp, Rahway, NJ 07065 USA

来源：

SYNLETT | 2006年 / 18期

关键词：

Heck reactions; Pd; kinetic screening; reaction calorimetry;

D O I：

10.1055/s-2006-951514

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Comprehensive kinetic screening of Pd catalysts for Heck reactions via a consecutive pulse reaction methodology allows a more informed choice of catalyst for a particular transformation, taking into account not only initial reactivity but also long-term catalyst stability. Competitive reactions also offer mechanistic information. The resting state and rate-limiting step within the catalytic cycle are found to be the same for phospha- and azapallada-cycles and ligandless Pd(OAc)(2) but different for the zero valent complex Pd[P(t-BU)(3)](2).

引用

页码：3135 / 3139

页数：5

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