Guidelines of care for the management of psoriasis and psoriatic arthritis Section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents

被引：432

作者：

Menter, Alan ^{[2
]}

Korman, Neil J. ^{[3
]}

Elmets, Craig A. ^{[4
]}

Feldman, Steven R. ^{[5
]}

Gelfand, Joel M. ^{[6
,7
]}

Gordon, Kenneth B. ^{[8
,9
]}

Gottlieb, Alice B. ^{[10
]}

Koo, John Y. M. ^{[11
]}

Lebwohl, Mark ^{[12
]}

Lim, Henry W. ^{[13
]}

Van Voorhees, Abby S. ^{[14
]}

Beutner, Karl R. ^{[11
,15
]}

Bhushan, Reva ^{[1
]}

机构：

[1] Amer Acad Dermatol, Schaumburg, IL USA

[2] Baylor Univ, Med Ctr, Dallas, TX USA

[3] Univ Hosp, Case Med Ctr, Dept Dermatol, Murdough Family Ctr Psoriasis, Cleveland, OH USA

[4] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL 35294 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Dermatol, Winston Salem, NC 27103 USA

[6] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA

[7] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[8] Evanston NW Healthcare, Div Dermatol, Chicago, IL USA

[9] Northwestern Univ, Dept Dermatol, Fienberg Sch Med, Chicago, IL 60611 USA

[10] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA

[11] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[12] Mt Sinai Sch Med, Dept Dermatol, New York, NY USA

[13] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA

[14] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA

[15] Anacor Pharmaceut Inc, Palo Alto, CA USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2009年 / 61卷 / 03期

关键词：

RENAL-TRANSPLANT RECIPIENTS; INTERMITTENT SHORT COURSES; DOSE METHOTREXATE THERAPY; CHRONIC PLAQUE PSORIASIS; PLACEBO-CONTROLLED TRIAL; LONG-TERM METHOTREXATE; FUMARIC-ACID THERAPY; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; CYCLOSPORINE-A;

D O I：

10.1016/j.jaad.2009.03.027

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this fourth of 6 sections of the guidelines of care for psoriasis, we discuss the use Of traditional systemic medications for the treatment of patients with psoriasis. Treatment should be tailored to meet individual patients' needs. We will discuss in detail the efficacy and safety, and offer recommendations for the use of the 3 most commonly used, and approved, traditional systemic agents: methotrexate, cyclosporine, and acitretin. We will also briefly discuss the available data for the use of azathioprine, fumaric acid esters, hydroxyurea, leflunomide, mycophenolate mofetil, sulfasalazine, tacrolimus, and 6-thioguanine in psoriasis. (J Am Acad Dermatol 2009;61:451-85.)

引用

页码：451 / 485

页数：35

共 186 条

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Monitoring methotrexate-induced hepatic fibrosis in patients with psoriasis: are serial liver biopsies justified? [J].