Fungal transformations of steroids by Cephalosporium aphidicola and Trichothecium roseum

被引：13

作者：

Atta-Ur-Rahman ^{[1
]}

Choudhary, MI ^{[1
]}

Asif, F ^{[1
]}

Farooq, A ^{[1
]}

Yaqoob, M ^{[1
]}

机构：

[1] Univ Karachi, Inst Chem Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT LETTERS | 2000年 / 14卷 / 03期

关键词：

fungal transformation; dehydroepiandrosterone; androsterone; Cephalosporium aphidicola; Trichothecium roseum; 3; beta-hydroxyandrost-4-en-17-one; beta; 4; beta-dihydroxyandrost-5-en-17-one; alpha; 17; beta-dihydronyandrostane;

D O I：

10.1080/10575630008041234

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transformation of dehydroepiandrosterone (1) was carried out by incubation with the fungus Cephalosporium aphidicola to obtain 3 beta-hydroxyandrost-4-en-17-one (2) and 3 beta,4 beta-dihydroxyandrost-5-en- 17-one (3). The fermentation of androsterone (4) by Trichothecium roseum afforded 3 alpha,17 beta-dihydroxyandrostane (5).

引用

页码：217 / 224

页数：8

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