SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

被引：189

作者：

Tzur, Yonatan B.

Wilson, Katherine L. ^{[1
]}

Gruenbaum, Yosef

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, IL-91904 Jerusalem, Israel

[2] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 10期

基金：

以色列科学基金会; 美国能源部; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.

引用

页码：782 / 788

页数：8

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