Intrinsic cellular defense mechanisms targeting human cytomegalovirus

被引：58

作者：

Tavalai, Nina ^{[1
]}

Stamminger, Thomas ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany

来源：

VIRUS RESEARCH | 2011年 / 157卷 / 02期

关键词：

HCMV; Nuclear domain 10; PML nuclear bodies; PML; Sp100; hDaxx; ATRX; Antiviral defense; Intrinsic immunity; PML NUCLEAR-BODIES; VIRAL GENE-EXPRESSION; PP71; PROTEIN; DOMAIN; 10; MEDIATED REPRESSION; CHROMATIN-STRUCTURE; IMMUNE DEFENSE; PRODUCT PP71; IE1; ND10;

D O I：

10.1016/j.virusres.2010.10.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent studies we and others have identified the cellular proteins PML, hDaxx, Sp100 and ATRX, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract cytomegalovirus infections by inhibiting the initiation of viral immediate-early (IE) gene expression. The antiviral function of ND10, however, is antagonized by viral regulatory proteins which either induce a proteasomal degradation of ND10 proteins or a disruption of the subnuclear structure. This review will summarize our current knowledge on the inhibition of cytomegalovirus replication by ND10 proteins. Furthermore, viral strategies to defeat this host defense mechanism are discussed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：128 / 133

页数：6

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