Effects of Selerocarya birrea (A. rich) hochst (anacardiaceae) leaf extracts on calcium signalling in cultured rat skeletal muscle cells

被引：11

作者：

Belemtougri, RG

Constantin, B

Cognard, C

Raymond, G

Sawadogo, L

机构：

[1] Univ Poitiers, CNRS, UMR 6558, LBSC, F-86022 Poitiers, France

[2] Univ Ouagadougou, Physiol Anim Lab, Fac Sci & Tech, Ouagadougou, Burkina Faso

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2001年 / 76卷 / 03期

关键词：

Sclerocarya birrea; Anacardiaceae; caffeine; skeletal muscle cells; intracellular calcium; sarcoplasmic reticulum;

D O I：

10.1016/S0378-8741(01)00248-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sclerocarya birrea is a plant used widely to treat many diseases in Burkina Faso, although no scientific data has been reported about its mechanism of action, In the present study the effects of its leaf extracts were investigated on calcium signalling in rat cultured skeletal muscle cells. The results show that the different extracts (crude decoction, aqueous, ethanolic and chloroformic extracts) have significant antagonistic effect on caffeine-induced calcium release from sarcoplasmic reticulum. Crude decoction is the most active followed by ethanolic, aqueous and chloroformic extracts in dose-dependent manner and can partly justify the use of the plant in traditional medicine. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：247 / 252

页数：6

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