Molecular mechanisms of enteroendocrine differentiation

被引:52
作者
Höcker, M [1 ]
Wiedenmann, B [1 ]
机构
[1] Humboldt Univ, Klinikum Charite, Med Klin Schwerpunkt Hepatol & Gastroenterol, D-13353 Berlin, Germany
来源
INTESTINAL PLASTICITY IN HEALTH AND DISEASE | 1998年 / 859卷
关键词
D O I
10.1111/j.1749-6632.1998.tb11120.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Passing through a complex series of developmental steps, the visceral endoderm differentiates into four intestinal epithelial lineages comprising enterocytes, goblet cells, paneth cells, and enteroendocrine cells. The intestinal enteroendocrine system consists of at least 15 different cell types, which can be classified on the basis of morphological criteria, expression of secretory products, and abundance of specific marker molecules. During intestinal development and in the adult gut, neuroendocrine subpopulations display strictly controlled differences in their geographical distribution that go along with dramatic differences in cell type-specific gene expression. Identification to transcription factors and regulatory DNA elements responsible for cell-specific gene expression in different neuroendocrine cell types as well as various transgenic and "knock-out" mouse models have largely added to our understanding of mechanisms controlling appropriate spacial and temporal activation of enteroendocrine differentiation programs. This article reviews current in vitro and in vivo studies analyzing different molecular aspects of enteroendocrine differentiation. In addition, the influence of intestinal diseases including malignant transformation on enteroendocrine differentiation and the underlying mechanisms will be discussed.
引用
收藏
页码:160 / 174
页数:15
相关论文
共 91 条
[1]   Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats [J].
Babyatsky, MW ;
deBeaumont, M ;
Thim, L ;
Podolsky, DK .
GASTROENTEROLOGY, 1996, 110 (02) :489-497
[2]   p53 Tumour suppressor gene expression in pancreatic neuroendocrine tumour cells [J].
Bartz, C ;
Ziske, C ;
Wiedenmann, B ;
Moelling, K .
GUT, 1996, 38 (03) :403-409
[3]   INCREASED POPULATIONS OF ENDOCRINE-CELLS IN CROHNS ILEITIS [J].
BISHOP, AE ;
PIETROLETTI, R ;
TAAT, CW ;
BRUMMELKAMP, WH ;
POLAK, JM .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1987, 410 (05) :391-396
[4]   INTESTINAL HYPERTROPHY FOLLOWING PARTIAL RESECTION OF THE SMALL BOWEL IN THE RAT [J].
BOOTH, CC ;
EVANS, KT ;
MENZIES, T ;
STREET, DF .
BRITISH JOURNAL OF SURGERY, 1959, 46 (198) :403-410
[5]   RECIPROCAL REGULATION OF ANTRAL GASTRIN AND SOMATOSTATIN GENE-EXPRESSION BY OMEPRAZOLE-INDUCED ACHLORHYDRIA [J].
BRAND, SJ ;
STONE, D .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (03) :1059-1066
[6]   DIFFERENTIATION OF RAT SMALL INTESTINAL EPITHELIAL-CELLS BY EXTRACELLULAR-MATRIX [J].
CARROLL, KM ;
WONG, TT ;
DRABIK, DL ;
CHANG, EB .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (03) :G355-G360
[7]  
CHANDRASEKARAN C, 1993, P NATL ACAD SCI USA, V90, P887
[8]   EXPRESSION OF GROWTH-FACTOR PEPTIDES AND THEIR RECEPTORS IN NEUROENDOCRINE TUMORS OF THE DIGESTIVE-SYSTEM [J].
CHAUDHRY, A ;
FUNA, K ;
OBERG, K .
ACTA ONCOLOGICA, 1993, 32 (02) :107-114
[9]  
CHAUDHRY A, 1994, CANCER RES, V54, P981
[10]  
CHAWENGSAKOPHAK K, 1997, NATURE, V386, P8487