Pentacyclic triterpenes from the resin of Liquidambar formosana

被引：33

作者：

Yang, Nian-Yun ^{[1
]}

Chen, Jian-Hua ^{[2
]}

Zhou, Gui-Sheng ^{[1
]}

Tang, Yu-Ping ^{[1
]}

Duan, Jin-Ao ^{[1
]}

Tian, Li-Juan ^{[3
]}

Liu, Xun-Hong ^{[4
]}

机构：

[1] Nanjing Univ Tradit Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

[2] So Med Univ, Affiliated Maoming Peoples Hosp, Maoming 525000, Peoples R China

[3] Jinling Pharmaceut Co Ltd, Ctr Tech, Nanjing 210009, Peoples R China

[4] Nanjing Univ Tradit Chinese Med, Coll Pharm, Nanjing 210046, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 06期

关键词：

Liquidambaris Resina; Hamamelidaceae; Pentacyclic triterpene; Cytotoxicity; MDA-MB-435S; Antiplatelet aggregation; LEAVES;

D O I：

10.1016/j.fitote.2011.05.003

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two new pentacyclic triterpenes and eight known pentacyclic triterpenes were isolated from the petroleum ether extract of Liquidambaris Resina. The structural elucidation of these compounds was determined by spectroscopic data interpretation. Their cytotoxic and antiplatelet aggregation activities were examined to find potent cytotoxic and antiplatelet aggregation compounds from natural resources. The results showed that 3-keto oleane triterpenes had strong cytotoxicity against MDA-MB-435S cancer cells and that 28-carboxyl oleane triterpenes possessed significant inhibition of platelet aggregation induced by ADP. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：927 / 931

页数：5

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