Low dose mercury toxicity and human health

被引:933
作者
Zahir, F [1 ]
Rizwi, SJ
Haq, SK
Khan, RH
机构
[1] AMU, JN Med Coll, Interdisciplinary Brain Res Ctr, Aligarh, Uttar Pradesh, India
[2] AMU, Interdisciplinary Biotechnol Unit, Aligarh, Uttar Pradesh, India
关键词
mercury pollution; low dose toxicity; biomagnification; neurodegenerative disorders;
D O I
10.1016/j.etap.2005.03.007
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Post Minamata incident there has been awareness about mercury toxicity even among the general public. Previous researches contributed a vast amount of data regarding acute mercury exposure, but gradually information about the low dose [Ninomiya, T., Ohmori, H., Hashimoto, K., Tsuruta, K., Ekino, S., 1995. Expansion of methylmercury poisoning outside minamata: an epidemiological study on chronic methylmercury poisoninig outside of Minamata. Environ. Res. 70 (1) 47-50; Lebel, J., Mergler, D., Lucotte, M., Amorim, M., Dolbec, J., Miranda, D., Arantes, G., Rheault, L, Pichet, P., 1996. Evidence of early nervous system dysfunction in Amazonian populations exposed to low-levels of methylmercury. Neurotoxicology 17 (1) 157-167] of mercury toxicity has been trickling in. With mercury contaminating rain-, ground and sea-water no one is safe. Polluted water leads to mercury laced fish, meat and vegetable. In aquatic environments, inorganic mercury is microbiologically transformed into lipophilic organic compound 'methylmercury'. This transformation makes mercury more prone to biomagnification in food chains. Consequently, populations with traditionally high dietary intake of food originating from fresh or marine environment have highest dietary exposure to mercury. Extensive research done on locals across the globe have already established this, persons who routinely consume fish or a particular species of fish are at an increased risk of methylmercury poisoning. The easy access of the toxicant to man through multiple pathways air, water, food, cosmetic products and even vaccines increase the exposure. Foetus and children are more susceptible towards mercury toxicity. Mothers consuming diet containing mercury pass the toxicant to foetus and to infants through breast milk. Decreased performance in areas of motor function and memory has been reported among children exposed to presumably safe mercury levels. Similarly, disruption of attention, fine motor function and verbal memory was also found in adults on exposure to low mercury levels. It is an occupational hazard for dental staff, chloralkali factory workers and goldminers, etc. Mercury has been found to be a causative agent of various sorts of disorders, including neurological, nephrological, immunological, cardiac, motor, reproductive and even genetic. Recently heavy metal mediated toxicity has been linked to diseases like Alzeihemer's, Parkinson's, Autism, Lupus, Amyotrophic lateral sclerosis, etc. Besides this, it poses danger to wildlife. Therefore, it becomes imperative to spread the information regarding the threat of mercury exposure amongst the scientists and masses.
引用
收藏
页码:351 / 360
页数:10
相关论文
共 103 条
[1]  
ALI SF, 1992, NEUROTOXICOLOGY, V13, P637
[2]   Accumulation of mercury in edible macrofungi:: Influence of some factors [J].
Alonso, J ;
Salgado, MJ ;
García, MA ;
Melgar, MJ .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2000, 38 (02) :158-162
[3]   MICRONUCLEI INDUCED BY SELENIUM, MERCURY, METHYLMERCURY AND THEIR MIXTURES IN BINUCLEATED BLOCKED FISH ERYTHROCYTE CELLS [J].
ALSABTI, K .
MUTATION RESEARCH, 1994, 320 (1-2) :157-163
[4]   Cytogenetic damage related to low levels of methyl mercury contamination in the Brazilian Amazon [J].
Amorim, AIM ;
Mergler, D ;
Bahia, MO ;
Dubeau, H ;
Miranda, D ;
Lebel, J ;
Burbano, RR ;
Lucotte, M .
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2000, 72 (04) :497-507
[5]   The role of sport-fish consumption advisories in mercury risk communication: a 1998-1999 12-state survey of women age 18-45 [J].
Anderson, HA ;
Hanrahan, LP ;
Smith, A ;
Draheim, L ;
Kanarek, M ;
Olsen, J .
ENVIRONMENTAL RESEARCH, 2004, 95 (03) :315-324
[6]   Episodes of elevated methylmercury concentrations in prairie streams [J].
Balogh, SJ ;
Huang, YB ;
Offerman, HJ ;
Meyer, ML ;
Johnson, DK .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2002, 36 (08) :1665-1670
[7]   FLUCTUATION OF TRACE-ELEMENTS DURING METHYLMERCURY TOXICATION AND CHELATION-THERAPY [J].
BAPU, C ;
PUROHIT, RC ;
SOOD, PP .
HUMAN & EXPERIMENTAL TOXICOLOGY, 1994, 13 (12) :815-823
[8]   ENDOCRINE FUNCTION IN MERCURY EXPOSED CHLORALKALI WORKERS [J].
BARREGARD, L ;
LINDSTEDT, G ;
SCHUTZ, A ;
SALLSTEN, G .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1994, 51 (08) :536-540
[9]   Horizontal and vertical variabilities of mercury concentration and speciation in sediments of the Gdansk Basin, Southern Baltic Sea [J].
Beldowski, J ;
Pempkowiak, J .
CHEMOSPHERE, 2003, 52 (03) :645-654
[10]   Genotoxicity of inorganic mercury salts based on disturbed microtubule function [J].
Bonacker, D ;
Stoiber, T ;
Wang, MS ;
Böhm, KJ ;
Prots, I ;
Unger, E ;
Thier, R ;
Bolt, HM ;
Degen, GH .
ARCHIVES OF TOXICOLOGY, 2004, 78 (10) :575-583