Vinflunine: a novel antitubulin agent in solid malignancies

被引：39

作者：

Bennouna, J ^{[1
]}

Campone, M ^{[1
]}

Delord, JP ^{[1
]}

Pinel, MC ^{[1
]}

机构：

[1] Ctr Rene Gauducheau, St Herblain, France

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2005年 / 14卷 / 10期

关键词：

bladder; breast; carcinoma; lung; vinflunine;

D O I：

10.1517/13543784.14.10.1259

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vinflunine is the first bi-fluorinated, tubulin-targeted agent that was obtained by semisynthesis using super-acidic chemistry, which allowed the selective introduction of two fluorine atoms at the C20' position of vinorelbine. This compound has been selected for clinical development on the basis of promising preclinical activity that warranted a study in patients with a wide spectrum of solid tumours. Clinically significant activity was seen in the Phase 11 studies for the treatment of bladder, non-small cell lung and breast cancers, thus prompting the initiation of the Phase III trials that are currently ongoing.

引用

收藏

页码：1259 / 1267

页数：9

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