Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats

被引：57

作者：

Cornish, JL ^{[1
]}

Shahnawaz, Z ^{[1
]}

Thompson, MR ^{[1
]}

Wong, S ^{[1
]}

Morley, KC ^{[1
]}

Hunt, GE ^{[1
]}

McGregor, LS ^{[1
]}

机构：

[1] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 482卷 / 1-3期

关键词：

MDMA (3,4-methylenedioxymethamphetamine); temperature; self-administration;

D O I：

10.1016/j.ejphar.2003.09.060

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degreesC) relative to normal laboratory temperature (21 degreesC). In the intravenous drug self-administration paradigm, hot temperature (30 degreesC) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：339 / 341

页数：3

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