Roles for CCN2 in normal physiological processes

被引：110

作者：

Hall-Glenn, Faith ^{[1
]}

Lyons, Karen M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, UCLA Orthopaed Hosp, Dept Orthopaed Surg,Res Ctr Orthopaed Hosp 510, Los Angeles, CA 90095 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 19期

关键词：

CCN2; CTGF; Connective tissue growth factor; TISSUE-GROWTH-FACTOR; VASCULAR ENDOTHELIAL-CELLS; ANGIOGENESIS IN-VIVO; C-TERMINAL DOMAIN; FACTOR CTGF; INTEGRIN ALPHA(V)BETA(3); DIABETIC-NEPHROPATHY; SKELETAL DEVELOPMENT; PULMONARY-FIBROSIS; TRANSIENT FIBROSIS;

D O I：

10.1007/s00018-011-0782-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

CCN2, also known as connective tissue growth factor, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases. However, CCN2 and related family members are widely expressed during development. Recent studies using new genetic models are revealing that CCN2 has essential roles in the development of many tissues. This review focuses on current and emerging data on CCN2 and its functions in chondrogenesis and angiogenesis, and on new studies showing that CCN2 has essential functions during embryonic and postnatal development in a number of epithelial tissues.

引用

页码：3209 / 3217

页数：9

共 70 条

[1]

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β [J].