Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

被引：64

作者：

McDonald, LA ^{[1
]}

Abbanat, DR ^{[1
]}

Barbieri, LR ^{[1
]}

Bernan, VS ^{[1
]}

Discafani, CM ^{[1
]}

Greenstein, M ^{[1
]}

Janota, K ^{[1
]}

Korshalla, JD ^{[1
]}

Lassota, P ^{[1
]}

Tischler, M ^{[1
]}

Carter, GT ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(99)00242-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The spiroxins (1-5) were purified from the culture extract of a marine-derived fungus. Their unique bisnaphthospiroketal structures were established by NMR spectroscopy. In addition to cytotoxicity, these compounds showed antibiotic activity and were active in a mouse xenograft model against human ovarian carcinoma. The mechanism of action of these compounds was shown to be due, in part, to their effect on DNA. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2489 / 2492

页数：4

共 9 条

[1] Total syntheses of palmarumycins CP1 and CP2 and CJ-12,371:: novel spiro-ketal fungal metabolites [J].