Life in the Fast Lane: Mammalian Disease Models in the Genomics Era

被引：57

作者：

Dow, Lukas E. ^{[1
]}

Lowe, Scott W. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[2] Howard Hughes Med Inst, New York, NY 10065 USA

来源：

CELL | 2012年 / 148卷 / 06期

基金：

英国医学研究理事会;

关键词：

PLURIPOTENT STEM-CELLS; ZINC-FINGER NUCLEASES; ENGINEERED MOUSE MODELS; IN-VIVO; HUMANIZED MICE; KNOCKOUT RATS; EMBRYO MICROINJECTION; RNA INTERFERENCE; GENE CORRECTION; LIVER-CANCER;

D O I：

10.1016/j.cell.2012.02.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology. Recent advances in genomic technologies, rodent-modeling approaches, and the production of patient-derived reprogrammed cell lines now provide a plethora of complementary systems to study disease states and test new therapies. Continued evolution and integration of these model systems will be the key to realizing the benefits of the genomic revolution and refining our understanding and treatment of human diseases.

引用

页码：1099 / 1109

页数：11

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