Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization

被引：156

作者：

Culver, James C. ^{[1
]}

Hoffmann, Joseph C. ^{[2
]}

Poche, Ross A. ^{[1
]}

Slater, John H. ^{[2
]}

West, Jennifer L. ^{[2
]}

Dickinson, Mary E. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[2] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 17期

关键词：

tissue engineering; photolithography; hydrogel; two-photon microscopy; vascular niche; VASCULAR NICHE; STEM;

D O I：

10.1002/adma.201200395

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2344 / 2348

页数：5

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