Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis

被引：87

作者：

Haasper, C. ^{[1
]}

Kalmbach, M. ^{[1
]}

Dikos, G. D. ^{[2
]}

Meller, R. ^{[1
]}

Mueller, C. ^{[1
]}

Krettek, C. ^{[1
]}

Hildebrand, F. ^{[1
]}

Frink, M. ^{[1
]}

机构：

[1] Hannover Med Sch MHH, Trauma Dept, Hannover, Germany

[2] Indiana Univ Sch Med, Dept Orthopaed Surg, Indianapolis, IN USA

来源：

TECHNOLOGY AND HEALTH CARE | 2010年 / 18卷 / 02期

关键词：

Multiple trauma; inflammatory mediators; SIRS; MODS; sepsis; survival; prediction; INFLAMMATORY RESPONSE SYNDROME; C-REACTIVE PROTEIN; RESPIRATORY-DISTRESS-SYNDROME; CALCITONIN PRECURSORS; SERUM PROCALCITONIN; BLUNT TRAUMA; CYTOKINES; FAILURE; MORTALITY; FRACTURES;

D O I：

10.3233/THC-2010-0571

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Despite recent advances in treatment of severe injured patients, e.g. due to damage control orthopaedics, multi organ dysfunction syndrome (MODS) and sepsis are major complications in daily practice. During one year 94 patients were prospectively collected. Inclusion criteria: ISS >= 16, age 18-60 y, primary admission to our level-1 trauma center, survival > 48 hours after trauma. The development of MODS and sepsis were observed and different groups were formed (+/-). Demographic data revealed no significant differences between the subgroups. Comparing groups +MODS and -MODS significant differences on admission day were observed, when PCT showed first on day 2 after trauma differences. Regarding the development of sepsis PCT was advantageous to IL-6 showing significant higher plasma levels in group +sepsis from the first day after trauma. Serum levels of IL-6 and PCT could be useful in early identification of high risk patients to develop posttraumatic MODS. For sepsis PCT is the better prognostic factor.

引用

页码：89 / 100

页数：12

共 47 条

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