The mechanisms of vision loss associated with a cotton wool spot

被引：22

作者：

Chui, Toco Y. P. ^{[1
]}

Thibos, Larry N. ^{[1
]}

Bradley, Arthur ^{[1
]}

Burns, Stephen A. ^{[1
]}

机构：

[1] Indiana Univ, Sch Optometry, Bloomington, IN 47405 USA

来源：

VISION RESEARCH | 2009年 / 49卷 / 23期

关键词：

Cotton wool spot; Retinal nerve fiber layer; Retinal sampling; Adaptive optics; Scanning laser ophthalmoscope; Optical coherence tomography; OPTICAL COHERENCE TOMOGRAPHY; GANGLION-CELL DEATH; PERIPHERAL-VISION; RETINAL FUNCTION; IN-VIVO; RESOLUTION; ISCHEMIA; OCCLUSION; SURVIVAL; BIREFRINGENCE;

D O I：

10.1016/j.visres.2009.08.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We characterized the perceptual, functional, and structural abnormalities associated with retinal ischemia during a cotton wool spot episode and its sequelae. The border of the visually salient field anomaly mirrored the quantitatively measured relative scotoma. Results of resolution perimetry and high resolution imaging indicated that there was a substantial loss of retinal ganglion cells within the affected region. A disruption in retinal nerve fiber arrangement was found at the cotton wool spot and within the arcuate relative scotoma. The presence of the arcuate relative scotoma is consistent with the hypothesis of failed signal transmission along the axons that pass through the cotton wool spot. The different levels of loss associated with the arcuate and focal scotomas indicate different underlying pathologies. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2826 / 2834

页数：9

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